2022.05-至今 安徽医科大学，bat36中国官方网站，副教授
2019.09-2021.08 纽约州立大学博士后
2010.08-2019.08 俄勒冈健康科技大学博士后
2007.09-2010.09 中科院广州生物医药与健康研究院 博士
基因表达调控形成复杂的网络，并精细的控制细胞命运和分化发育，其失调导致疾病的发生。本课题组以神经系统脊髓为研究系统，采用干细胞、组学以及动物模型等多种前沿手段系统剖析神经细胞的特异性产生和分化发育的分子细胞机制，着重研究表观遗传因子在神经细胞命运决定和发育过程中对基因表达网络的调控机制以及在疾病发生发展过程中的表观遗传机制，并探讨干细胞定向分化的潜在应用。
1. Wang W, Cho H, Lee J, Lee S*. The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development. Nature Communications. 2022 Feb 17;13(1):958.
2. Wang W, Cho H, Kim D, Park Y, Moon JH, Lim SJ, Yoon SM, McCane M, Aicher SA, Kim S, Emery B, Lee J, Lee S, Park Y, Lee S*. PRC2 acts as a critical epigenetic timer that drives oligodendrocyte fate over astrocyte identity by repressing the Notch pathway. Cell reports. 2020 Sep 15;32(11):108147.
3. Wang W, Wong CW*. Statins enhance peroxisome proliferator-activated receptor gamma coactivator-1alpha activity to regulate energy metabolism. J Mol Med. 2010 Mar 88(3):309-17
4. Lu N#, Wang W#, Liu J, Wong CW*. Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha. Cellular Signaling. 2011 Sep 23(9):1473-8
5. Gao M, Wang J, Wang W, Liu J, Wong CW*. Phosphatidylinositol 3-kinase affects mitochondrial function in part through inducing peroxisome proliferator-activated receptor γ coactivator-1β expression. Br J Pharmacol. 2011 Feb 162(4):1000-8.
6. Wang WX, Wang YP, Deng XJ, Dang XL, Tian JH, Yi HY, Li YF, He XF, Cao Y, Xia QY, Lai R, Wen SY*. Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis. J Insect Sci. 2009 May 9(17):1-13.
7. Dang XL, Tian JH, Yang WY, Wang WX, Ishibashi J, Asaoka A, Yi HY, Li YF, Cao Y, Yamakawa M, Wen SY*. Bactrocerin-1: a novel inducible antimicrobial peptide from pupae of oriental fruit fly Bactrocera dorsalis Hendel. Arch Insect Biochem Physiol. 2009 Jul 71(3):117-29.
8. Dang XL, Tian JH, Yi HY, Wang WX, Zheng M, Li YF, Cao Y, Wen SY*. Inducing and isolation of antibacterial peptides from oriental fruit fly, Bactrocera dorsalis Hendel. Insect Science. 2006 August 13(4):257-262.
1. 国家自然科学基金面上项目，Kdm6b参与脊髓运动神经元分化发育的分子机理研究，2023/01-2026/12, 主持；
2. 安徽医科大学引进人才科研启动项目，2022/05-2026/04, 主持.
