2023.01-至今 安徽医科大学,bat36中国官方网站,副教授
2018.07-2022.12 苏州大学,苏州医学院,副教授
2013.09-2018.06 苏州大学,苏州医学院,讲师
2012.07-2013.07 中国科学院,武汉病毒研究所,助理研究员
2009.09-2012.06 暨南大学生命科学技术学院,博士
本课题组主要从事抗感染免疫方面的研究工作,主要包括:
1、宿主因子抗病毒天然免疫的作用及其调控机制;
2、天然产物、小分子药物的抗病毒作用及其机制;
3、病毒的免疫逃逸作用及其分子机制。
1. Wang K#, Huang C#, Jiang T, Chen Z, Xue M, Zhang Q, Zhang J, Dai J*. RNA-binding protein RBM47 stabilizes IFNAR1 mRNA to potentiate host antiviral activity. EMBO Rep. 2021 Aug 4; 22 (8): e52205.
2. Wang K#, Zhang J#, Ge Y#, Dong C, Dai J*. Cyclovirobuxine D inhibits dengue virus replication by impeding the complete autophagy in a cholesterol-dependent manner. Sci Bull. 2021 Feb 15; 66 (3): 284-296.
3. Wang K#, Zou C#, Wang X#, Huang C, Feng T, Pan W, Wu Q, Wang P, Dai J*. Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3. PLoS Pathog. 2018 Aug 24; 14 (8): e1007287.
4. Wang K#, Ni L#, Wang S, Zheng C*. Herpes simplex virus 1 protein kinase US3 hyperphosphorylates p65/RelA and dampens NF-κB activation. J Virol. 2014 Jul; 88 (14): 7941-51.
5. Wang K#, Wang J#, Sun T, Bian G, Pan W, Feng T, Wang P, Li Y*, Dai J*. Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication. Int J Biol Sci. 2016 May 25; 12 (7): 872-83.
6. Wang J#, Jiang B#, Wang K#, Dai J, Dong C, Wang Y, Zhang P, Li M, Xu W*, Wei L*. A cathelicidin antimicrobial peptide from Hydrophis cyanocinctus inhibits Zika virus infection by downregulating expression of a viral entry factor. J Biol Chem. 2022 Oct; 298 (10): 102471.
7. Cai M#, Xiao B#, Wang Y#, Wang K#, Luo W, Fu J, Wang S, Deng S, Li B, Gong L, Zhong J, Hu L, Pan L, Wang L, Liu Y, Huang C, Li X, Zeng Q, Kang H, Li L, Zan J*, Peng T*, Yang H*, Li M*. Epstein-Barr virus envelope glycoprotein 110 inhibits NF-κB activation by interacting with NF-κB subunit p65. J Biol Chem. 2023 May; 299 (5): 104613.
8. Zhang Q#, Chen Z#, Huang C#, Sun J, Xue M, Feng T, Pan W, Wang K*, Dai J*. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) and Spike (S) Proteins Antagonize Host Type I Interferon Response. Front Cell Infect Microbiol. 2021 Dec 7; 11: 766922.
9. Huang C#, Jiang T#, Xue M#, Li Y, Feng T, Pan W, Wang K*, Dai J*. Poly(C)-binding protein 2 positively regulates interferon downstream signaling. Acta Biochim Biophys Sin. 2022 May 25; 54 (5): 748-751.
10. Ge Y#, Zhang J#, Hou C#, Li Y, Huang C, Pan W, Zhang Q, Dai J*, Wang K*. Inhibitory effect of cyclocytidine hydrochloride on vesicular stomatitis virus infection. Acta Biochim Biophys Sin. 2020 May 26; 52 (5): 576-579.
1. 国家自然科学基金,面上项目,82371779,2024/1-2027/12, 主持;
2. 国家自然科学基金,青年项目,31500700,2016/1-2018/12, 主持;
3. 安徽省自然科学基金,面上项目,2308085MC77,2023/7-2026/6, 主持;
4. 安徽省高校科研基金,重点项目,2023AH050641,2023/9-2025/8, 主持;
5. 江苏省自然科学基金,青年项目,BK20140322,2014/7-2017/6, 主持;
6. 安徽医科大学,引进人才科研启动项目,0801056201,2023/1-2027/12, 主持;
7. 呼吸疾病国家重点实验室,开放课题项目,SKLRD-OP-202317, 2023/1-2025/12, 主持.