个人简介:
2019.07-至今 安徽医科大学,bat36中国官方网站,校聘副教授
2014.09-2019.06 武汉大学化学与分子科学学院,硕博连读
2010.09-2014.06 湖北师范大学化学与化工学院,学士
个人荣誉及学术任职
2022年 安徽医科大学“优秀教师”
2021年 安徽医科大学“復元科技新星”
2020年 安徽医科大学“优秀班主任”
恶性肿瘤是威胁人类健康最主要的疾病之一,本实验室的研究工作主要聚焦于肿瘤的诊断和治疗方面。近期的研究方向主要集中于以下三点:
1. 新型药物和基因传递系统的研究;
2. 疾病的诊断和治疗新材料的开发;
3. 通过研究肿瘤的发生的机制、肿瘤微环境与肿瘤恶化的关系,探索一些新型的肿瘤治疗思路。
1. Wang Q#, Qin W#, Qiao L#, Gao M, Zhou M, Zhang H, Sun Q, Yao W, Yang T, Ren X*, Sun G*, He X*. Biomimetic Nanophotosensitizer Amplifies Immunogenic Pyroptosis and Triggers Synergistic Cancer Therapy. Adv Healthc Mater. 2023 Aug 7:e2301641.
2. Han D, Ren X, Liao X, He X*, Guo T*, Chen X, Pang X, Cheng S*. A Multiple Targeting Nanoprobe for Identifying Cancer Metastatic Sites Based on Detection of Various mRNAs in Circulating Tumor Cells. Nano Lett. 2023 May 10;23(9):3678-3686.
3. Qiao L#, Gao M#, Yi X#, Peng H, Zhang R, Yao W, Sun G, He X*. Biomimetic gene editing system for precise tumor cell reprogramming and augmented tumor therapy. J Control Release. 2023 Apr;356:663-677.
4. Yang T#, Zhou M#, Gao M#, Qin W, Wang Q, Peng H, Yao W, Qiao L*, He X*. Carrier-Free H2O2 Self-Supplier for Amplified Synergistic Tumor Therapy. Small. 2023 Feb;19(7):e2205692.
5. Gao M#, Yang T#, Qin W#, Wang Q, Huang M, Peng H, Shao M, Yao W, Yi X, Sun G*, He X*. Cell Membrane-Anchoring Nano-Photosensitizer for Light-Controlled Calcium-Overload and Tumor-Specific Synergistic Therapy. Small. 2022 Dec;18(48):e2204689.
6. Peng H#, Qiao L*, Shan G, Gao M, Zhang R, Yi X, He X*. Stepwise responsive carboxymethyl chitosan-based nanoplatform for effective drug-resistant breast cancer suppression. Carbohydr Polym. 2022 Sep 1;291:119554.
7. Ren X#, Xu C, Li L, Zuo Y, Han D, He X*, Cheng S*. A targeting delivery system for effective genome editing in leukemia cells to reverse malignancy. J Control Release. 2022 Mar;343:645-656..
8. Qiao L#, Yuan X, Peng H, Shan G, Gao M, Yi X, He X*. Targeted delivery and stimulus-responsive release of anticancer drugs for efficient chemotherapy. Drug Deliv. 2021 Dec;28(1):2218-2228.
9. He X, Ren X, Peng Y, Zhang J, Ai S, Liu B, Xu C, Cheng S*. Aptamer/Peptide-Functionalized Genome-Editing System for Effective Immune Restoration through Reversal of PD-L1-Mediated Cancer Immunosuppression. Adv Mater. 2020 Apr;32(17):e2000208.
10. He X, Liu B, Peng Y, Zhuo R, Cheng S*. Multifunctional Vector for Delivery of Genome Editing Plasmid Targeting β-Catenin to Remodulate Cancer Cell Properties. ACS Appl Mater Interfaces. 2019 Jan 9;11(1):226-237.
1. 国家自然科学基金,仿生型肿瘤细胞核靶向传递系统递送CRISPR-Cas9质粒促使“免疫正常化”的研究,2021/1-2023/12, 主持;
2. 安徽省自然科学基金,基于天然高分子的多细胞协同作用系统用于肿瘤免疫调节的研究,2020/7-2022/6, 主持;
3. 安徽医科大学科研提升计划,2022/1-2025/12, 主持;
4. 安徽医科大学引进人才博士科研启动经费,2019/10-2024/9, 主持.