个人简介： 

2012.08-至今     安徽医科大学，bat36中国官方网站，副教授

2005.07-2012.07    安徽医科大学基础医学院，讲师

个人荣誉及学术任职

2017年                安徽省科学技术奖一等奖（排名第五）

教学领域

主要从事《细胞工程》、《微生物学》、《食品生物技术导论》及《生物技术综合实验》等课程教学工作。

        镉是环境中普遍存在的污染物，长期低剂量镉暴露会引起包括前列腺在内的多器官肿瘤。本实验室主要利用Western blotting、qPCR、ChIP、免疫荧光、活细胞成像和基因敲除等分子生物学技术，致力于探索低剂量镉暴露诱发前列腺肿瘤及其转移的分子机制。

1. Weirong Hu, Mizhen Xia#, Cheng Zhang, Bingdong Song, Zhengmei Xia, Dexiang Xu*, Jun Fang. Chronic cadmium exposure induces epithelial mesenchymal transition in prostate cancer cells through a TGF-β-independent, endoplasmic reticulum stress induced pathway. Toxicology Letters. 2021Dec15;353:107-117.

2. Guo C, Zhang C, Xia Z, Song B, Hu W, Cui Y, Xue Y, Xia M, Xu D, Zhang S, Fang J. Nano-designed CO donor ameliorates bleomycin-induced pulmonary fibrosis via macrophage manipulation. J Control Release. 2022 Jan;341:566-577.

3. Guo MY, Wang H, Chen YH, Xia MZ, Zhang C, Xu DX. N-acetylcysteine alleviates cadmium-induced placental endoplasmic reticulum stress and fetal growth restriction in mice. PLoS One. 2018 Jan 26;13(1):e0191667.

4. Xie DD, Chen YH, Xu S, Zhang C, Wang DM, Wang H, Chen L, Zhang ZH, Xia MZ, Xu DX, Yu DX. Low vitamin D status is associated with inflammation in patients with prostate cancer. Oncotarget. 2017 Mar 28;8(13):22076-22085.

5. Huang YY, Xia MZ#, Wang H, Liu XJ, Hu YF, Chen YH, Zhang C, Xu DX. Cadmium selectively induces MIP-2 and COX-2 through PTEN-mediated Akt activation in RAW264.7 cells. Toxicol Sci. 2014 Apr;138(2):310-21.

6. Zhang ZH, Xie DD, Xu S, Xia MZ, Zhang ZQ, Geng H, Chen L, Wang DM, Wei W, Yu DX, Xu DX. Total glucosides of paeony inhibits lipopolysaccharide-induced proliferation, migration and invasion in androgen insensitive prostate cancer cells. PLoS One. 2017 Aug 4;12(8):e0182584.

7. Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH. Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells. J Pineal Res. 2012 Nov;53(4):325-34. 

1. 安徽省教育厅自然科学基金，KJ2012A167，Kupffer细胞在LPS调控肝细胞LXR-α及其靶基因中的作用，2012/01-2014/12, 主持；

2. 国家自然科学基金重点项目，81630084，孕期维生素D缺乏与胎儿生长受限的关联及其机制研究，2017/01-2021/12, 参与.