2014.07-至今 安徽医科大学生命科学院,副教授
2011.07-2014.07 安徽医科大学生命科学院,讲师
2005.09-2011.07 厦门大学bat36中国官方网站,博士学位
2001.09-2005.07 河南师范大学bat36中国官方网站,学士学位
胚胎着床是雌性哺乳动物生殖过程中最关键的步骤之一,胚胎着床依赖于具有着床能力的胚泡和具有接受态子宫内膜建立紧密联系过程。子宫内膜与胚胎之间相互作用的同时,子宫内膜基质中的成纤维细胞发生广泛的增殖和分化,这个过程称蜕膜化。着床或蜕膜化失败则会导致胚胎无法继续发育,是导致不孕不育的重要原因之一。研究组主要利用小鼠模型结合人类临床标本和多种新兴研究方法,研究早期胚胎发育子宫接受态建立和蜕膜化的分子调控网络。通过揭示妊娠建立和维持的分子机理,为预防和治疗相关的生殖疾病提供参考和借鉴。
1. Zhang X, Liang X, Wang T, Liang X, Zuo R, Deng W, Zhang Z, Qin F, Zhao Z, Yang Z. Heparin-binding epidermal growth factor-like growth factor ( HB-EGF ) induction on snail expression during mouse decidualization. Mol. Cell. Endocrinol., 2013, 381(1-2): 272-9.
2. Liang X, Zhang X, Han B, Lei W, Qi Q, Wang T, Yang Z. Progesterone and heparin-binding epidermal growth factor-like growth factor regulate the expression of tight junction protein Claudin-3 during early pregnancy. Fertil. Steril., 2013, 100(5): 1410-8.
3. Zhang X, Liang X, Liang X, Wang T, Qi Q, Deng WB, Sha AG, Yang ZM. The mesenchymal-epithelial transition during in vitro decidualization. Reproductive sciences, 2013, 20(4): 354-60.
4. Zhang X, Tian Z, Lei W, Zhao Z, Wang T, Yang Z. Differential expression of interleukin-1 receptor type II during mouse decidualization. Reprod. sci., 2012, 19(9): 923-31.
5. Tian Z, Zhao ZA, Liang XH, Zhang X, Sha AG, Zhang ZR, Yu YS, Yang ZM. Expression and function of fatty acid-binding protein 4 during mouse decidualization. Fertil. Steril., 2011, 95: 2749-52.
6. Liang X, Zhao Z, Deng W, Tian Z, Lei W, Xu X, Zhang X, Su RW, Yang ZM. Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization. Endocrinology, 2010, 151(10): 5007-16.
7. Wu M, Sheng L, Cheng M, Zhang H, Jiang Y, Lin S, Liang Y, Zhu F, Liu Z, Zhang Y, Zhang X, Gao Q, Chen D, Li J, Li Y. Low doses of decitabine improve the chemotherapy efficacy against basal-like bladder cancer by targeting cancer stem cells. Oncogene, 2019, 38(27): 5425-5439.
8. Zhu F, Qian W, Zhang H, Liang Y, Wu M, Zhang Y, Zhang X, Gao Q, Li Y. SOX2 is a marker for stem-like tumor cells in bladder cancer. Stem Cell Rep., 2017, 9(2): 429-437.
1. 国家自然科学基金青年项目,31501838,MicroRNAs在小鼠子宫蜕膜化中基质上皮转换发生过程中的功能和分子机制研究,2016/01-2018/12,19万,主持
2. 安徽省教育厅自然科学基金重点项目,KJ2014A112、SUMO化修饰在小鼠胚胎着床过程中的作用、2014.01-2016.12,6万元,主持