个人简介： 

2018.07-至今   bat36中国官方网站，校聘副教授

2013.09-2018.06  南京师范大学bat36中国官方网站，博士

2009.09-2013.06       合肥师范学院，学士

神经退行性疾病是一种大脑和脊髓的细胞神经元丧失的疾病状态，包括帕金森病、阿尔茨海默病和亨廷顿式舞蹈症等疾病。本课题组特别关注氧化应激相关的神经退行性疾病，如帕金森病等的致病机理，并针对于此进行相关新药探索。近期主要研究神经细胞生存和死亡的信号转导网络，探索靶向药物调控的分子机制。

1. Wu K, Wang W, Cheng Q, Li H, Yan W, Zhou F, Zhang R*. Pyroptosis in neurodegenerative diseases: from bench to bedside. Cell Biol Toxicol. 2023 Jul 26.

2. Yu Q#, Zhang R#, Li T, Yang L, Zhou Z, Hou L, Wu W, Zhao R, Chen X, Yao Y, Huang S*, Chen L*. Mitochondrial Hydrogen Peroxide Activates PTEN and Inactivates Akt Leading to Autophagy Inhibition-Dependent Cell Death in Neuronal Models of Parkinson's Disease. Mol Neurobiol. 2023 Jun;60(6):3345-3364.

3. Zhang R, Liu C, Yang L, Ji T, Zhang N, Dong X, Chen X, Ma J, Gao W, Huang S*, Chen L*.  NOX2-derived hydrogen peroxide impedes the AMPK/Akt-mTOR signaling  pathway contributing to cell death in neuronal cells. Cell Signal. 2022, 94:110330.

4. Liu C#, Zhang R#, Yang L#, Ji T, Zhu C, Liu B, Zhang H, Xu C, Zhang N, Huang S*, Chen L*.  Neuroprotection of resveratrol against cadmium-poisoning acts through  dual inhibition of mTORC1/2 signaling. Neuropharmacology. 2022, 219:109236.

5. Zhang R, Zhang N, Zhang H, Liu C, Dong X, Wang X, Zhu Y, Xu C, Liu L, Yang S, Huang S*, Chen L*. Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species mediated mammalian target of rapamycin pathway. Br. J. Pharmacol., 2017, 174: 82-100.

6. Zhang R, Zhu Y, Dong X, Liu B, Zhang N, Wang X, Liu L, Xu C, Huang S*, Chen L*. Celastrol attenuates cadmium-induced neuronal apoptosis via inhibiting Ca2+-CaMKII-dependent Akt/mTor pathway. J. Cell. Physiol., 2017, 232: 2145-2157.

7. Liu C, Zhang R, Sun C, Zhang H, Xu C, Liu W, Gao W, Huang S*, Chen L*. Resveratrol prevents cadmium activation of Erk1/2 and JNK pathways from neuronal cell death via protein phosphatases 2A and 5. J. Neurochem., 2015, 135: 466-478.

8. Xu C, Liu C, Liu L, Zhang R, Zhang H, Chen S, Chen L*, Huang S*. Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways. Neuropharmacology, 2015, 97: 35-4.

9. Qian Z, Liu C, Liu W, Zhang H, Zhang R, Liu J, Zhang J, Xu C, Liu L, Huang S*, Chen L*. Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis. Toxicol Sci., 2015, 143: 81-96.

1. 国家自然科学基金，Rac1香叶酰香叶酰化修饰在帕金森病发生中的作用与分子机理研究，2022/01-2024/12, 主持；

2. 安徽医科大学校科研基金项目，2019/01-2020/12, 主持；

3. 安徽医科大学博士人才引进科研启动基金，2019/01-2022/01, 主持.