国家杰出青年和国家优秀青年基金获得者。曾入选国家百千万人才工程、教育部新世纪人才和安徽省 “皖江学者”特聘教授。安徽医科大学第一附属医院肿瘤内科副主任,兼肿瘤免疫病区主任;安徽医科大学科技产业处处长。
1994 - 1999 毕业于安徽医科大学医学系临床医学专业,学士。
2005 获安徽医科大学临床药理研究所药理学博士学位。
2007 - 2014 在美国国立卫生研究院(NIH)酒精滥用与依赖研究所(NIAAA)肝病实验室开展科学研究。
2015 获安徽省青年科技奖和吴孟超青年奖。
2019 获安徽省自然科学奖一等奖(排名第2)。
主要研究方向为肝损伤炎症与修复、肿瘤免疫,及相关药物研发。代表作发表在Hepatology,Journal of Hepatology,Gastroenterology,The American Journal of Pathology等。
1. Ren R, Yong He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B, Wang H*. Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis. Hepatology.2022 Mar;75(3):646-660. doi: 10.1002/hep.32152.
2. Hou X#, Yin S#, Ren R, Liu S, Yong L, Liu Y, Li Y, Zheng MH, Kunos G, Gao B, Wang H* Myeloid cell-specific IL-6 signaling promotes miR-223-enriched exosome production to attenuate NAFLD-associated fibrosis. Hepatology. 2021 Jul;74(1):116-132.(Editorial comment: Gyongyi Szabo. Exosomes and MicroRNA-223 at the Intersection of Inflammation and Fibrosis in NAFLD. Hepatology; 2021 Jul;74(1):5-8. doi: 10.1002/hep.31805. Epub 2021 May 24.)
3. Wang H*, Mehal W, Nagy LE, Rotman Y. Immunological mechanisms and therapeutic targets of fatty liver diseases. Cell Mol Immunol. 2021. Jan;18(1):73-91. (Invited Review, Cover Figure)
4. Xu L#,Yang Y#,Wen X, Jeong J, Emontzpohl C, Atkins C, Sun Z, Poulsen K, Hall D, Bynon J, Gao B, Lee W, Rule J, Jacobsen E, Wang H*, Ju C*. Hepatic recruitment of eosinophils and their protective function during acute liver injury. J of Hepatol. 2022, Aug;77(2):344-352. doi: 10.1016/j.jhep.2022.02.024.
5. Xu L#, Yang Y#, Jiang J, Wen Y, Jeong JM, Emontzpohl C, Atkins CL, Kim K, Jacobsen EA, Wang H*, Ju C*. Eosinophils protect against acetaminophen-induced liver injury through cyclooxygenase-mediated IL-4/IL-13 production. Hepatology. 2022 Jun 17. doi: 10.1002/hep.32609.
6. Xiao J#, Wang F#, Wong NK, He J, Zhang R, Sun R, Xu Y, Liu Y, Li W, Koike K, He W, You H, Miao Y, Liu X, Meng M, Wang H*, Li C*. Global Liver Disease Burdens and Research Trends: Analysis from a China Perspective. J Hepatol. 2019 Jul;71(1):212-221. (Public Health)
7. Liu JT#, Fan LL#, Yu HQ#, Zhang J#, He Y, Feng DC, Wang F, Li XQ, Liu QQ, Li YH, Guo ZL, Gao B, Wei W, Wang H*, Sun GP*. Endoplasmic reticulum stress promotes liver cancer cells to release exosomal miR-23a-3p and up-regulate PD-L1 expression in macrophages. Hepatology. 2019 Jul;70(1):241-258.
8. Ramirez T#, Li YM#, Yin S#, Xu MJ, Feng D, Zhou Z, Zang M, Mukhopadhyay P, Varga ZV, Pacher P, Gao B*, Wang H*. Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating Sirtuin 1 expression. J Hepatol. 2017; 66(3):601-609.(Cover Story)
1. 炎症免疫性疾病优秀科研创新团队,2022AH010047,安徽省教育厅优秀科研创新团队项目.
2. 肝损伤炎症与修复,国家杰出青年科学基金,82225008/H03,2023.1-2027.12.
3. p21缺失通过调节肿瘤免疫微环境促进肝癌发生的机制研究,国家自然科学基金区域创新发展联合基金,U21A20375,2022.1-2025.12.
4. Alcoholic liver disease: from hepatitis to failure. 中德合作交流项目(The Mobility Programme of the Sino-German Center for Research Promotion),M-0099,2021.1-2023.12.
5. 髓系细胞在衰老加重酒精性肝病进程中的作用以及天然杀伤(NK)/NKT细胞的调节机制,国家自然科学基金面上项目,81770588/H0315,2018.1-2021.12.
6. 肝再生和损伤修复,国家优秀青年科学基金,81522009/H0317,2016.1-2018.12.
7. 髓系细胞STAT3在肝细胞癌微环境中可抑制抗肿瘤免疫反应,国家自然科学基金面上项目,81372577/ H1617,2014.1-2017.12.