T细胞激活后能够有效清除肿瘤和对抗病毒感染，但T细胞异常激活或Treg功能缺失，也会导致自身免疫病。本课题组致力于研究T细胞发育、分化、耗竭和死亡在抗肿瘤免疫和自身免疫病中的机制研究。结合安徽医科大学的临床资源优势，在今后的工作中着力于：
(1) 以系统性红斑狼疮、多发性硬化病为主的自身免疫病的免疫机理研究；
(2) 抗肿瘤免疫中CD8+T细胞和Treg细胞中新型免疫治疗靶点的筛选；
(3) 生殖和代谢类等疾病中免疫系统异常的机制研究。
1. Liu C#, Ma L#, Wang Y#, Chen P, Chen X, Liu Y, Jia X, Yang Z, Yin X, Wu J, Wu S, Zheng H, Ma X, Sun X, He Y, Lin L, Fu Y, Liao K, Zhou X, Jiang S , Fu G, Tang J, Chen X, Fan W, Hong Y, Han J, Xiao N, Xiao C*, Fu G*, Liu W*. Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt. Sci adv. 2021; 7: eabg6262.
2. Liu Q#, Zhou Y#, Ma L, Gu F, Liao K, Liu Y, Zhang Y, Liu H, Hong Y, Cao M, Liu W*, Liu C*, Liu G*. Sulfate oligosaccharide of Gracilaria lemaneiformis modulates type 1 immunity by restraining T cell activation. Carbohydrate Polymers. 2022 Jul 15;288:119377.
3. Wang X#*, Yin X#, Zhang B#, Liu C#, Lin Y, Huang X, Li Y, Shen C, Zheng W, Fu G, Chen J, Wen Y, Zhang W, Pan B, Fang M, Zheng Z, Zhang Z, Yuan Q, Fu G, Li S, Zhang J, Chen Y*, Xia N*, Zhao Q*. A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity. Emerg Microbes Infect. 2022 Dec;11(1):914-925.
4. Fu Y#, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N, Xiao C, Liu WH*. Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation. Cell Mol Immunol. 2023 Aug 9. doi: 10.1038/s41423-023-01075-0.
5. Shan W#, Zheng H#, Fu G, Liu C, Li Z, Ye Y, Zhao J, Xu D, Sun L, Wang X, Chen X, Bi S, Ren L*, Fu G*. Bioengineered Nanocage from HBc Protein for Combination Cancer Immunotherapy. Nano Lett. 2019 Mar 13;19(3):1719-1727.
6. Sun S#, Jiang Y#, Wang R#, Liu C, Liu X, Song N, Guo Y, Guo R, Du L, Jiang S, Li Y, Qiu Z, Zhao G*, Zhou Y*. Treatment of Paraquat-Induced Lung Injury With an Anti-C5a Antibody: Potential Clinical Application. Crit Care Med. 2018 May; 46 (5):e419-e425.
7. Sun S#, Zhao G#, Liu C, Fan W, Zhou X, Zeng L, Guo Y, Kou Z, Yu H, Li J, Wang R, Li Y, Schneider C, Habel M, Riedemann NC, Du L, Jiang S, Guo R, Zhou Y*. Treatment with anti-C5a antibody improves the outcome of H7N9 virus infection in African green monkeys. Clin Infect Dis. 2015 Feb 15;60(4):586-95.
8. Zhao G#, Liu C#, Kou Z#, Gao T, Pan T, Wu X, Yu H, Guo Y, Zeng Y, Du L, Jiang S, Sun S*, Zhou Y*. Differences in the Pathogenicity and Inflammatory Responses Induced by Avian Influenza A/H7N9 Virus Infection in BALB/c and C57BL/6 Mouse Models. PLoS One. 2014 Mar 9(3): e92987.
1. 国家自然科学基金青年项目，82202006，β-catenin缺失介导T细胞分化 异常在系统性红斑狼疮中的机制研究, 2023/1-2025/12, 主持；
2. 安徽省高校自然科学重点项目，GSK3调控Treg细胞中Foxp3稳定性在抗肿瘤免疫中的作用和机制研究，2023/1-2024/12, 主持；
3. 自然资源部第三海洋研究所横向基金，化合物ZBF6/11在T细胞中的作用和机制研究。2023/9-2024/9, 主持.
