2022.07-至今 安徽医科大学，bat36中国官方网站，校聘副教授
2017.09-2022.06 武汉大学，博士
2013.09-2017.06 华中农业大学，学士
本课题组主要利用天然功能化的药物和核酸传递系统在疾病诊断、治疗中的研究，以实现诊疗一体化。包括：
1. 天然功能化的核酸传递系统在疾病诊断中的研究；
2. 天然功能化的药物和核酸传递系统在疾病治疗中的研究；
3. 诊疗一体化新材料的开发。
1. Wang Q#, Qin WJ#, Qiao L#, Gao M, Zhou M, Zhang HR, Sun QT, Yao WQ, Yang TH, Ren XH*, Sun GY*, He XY*. Biomimetic nanophotosensitizer amplifies immunogenic pyroptosis and triggers synergistic cancer therapy. Adv Healthc Mater. 2023 Aug 7:e2301641.
2. Che YJ#, Ren XH#, Wang ZW*, Wu Q#, Xing K#, Zhang M, Xu C, Han D, Yuan S, Zheng SH, Chen YY, Liao XR, Shi F, Zhong XH, Cai X, Cheng SX*. Lymph-node-targeted drug delivery for effective immunomodulation to prolong the long-term survival after heart transplantation. Adv Mater. 2023 Apr;35(16):e2207227.
3. Ren XH, He XY, Xu C, Han D, Cheng SX*. Functional tumor targeting nano-systems for reprogramming circulating tumor cells with in situ evaluation on therapeutic efficiency at the single-cell level. Adv Sci. 2022 Jul;9(21):e2105806.
4. Ren XH, Xu C, Li LL, Zuo Y, Han D, He XY*, Cheng SX*. A targeting delivery system for effective genome editing in leukemia cells to reverse malignancy. J Control Release. 2022 Mar;343:645-656.
5. Ren XH, Han D, He XY, Guo T, Chen XS, Pang X, Cheng SX*. Multi-targeting nano-systems targeting heterogeneous cancer cells for therapeutics and biomarker detection. Adv Healthc Mater. 2023 Feb;12(4):e2202155.
6. Ren XH, He XY, Liu BY, Xu C, Cheng SX*. Self-assembled plasmid delivery system for ppm1d knockout to reverse tumor malignancy. ACS Appl Bio Mater. 2020 Nov 16;3(11):7831-7839.
7. Han D, Ren XH, Liao XR, He XY*, Guo T*, Chen XS, Pang X, Cheng SX*. A multiple targeting nanoprobe for identifying cancer metastatic sites based on detection of various mRNAs in circulating tumor cells. Nano Lett. 2023 May 10;23(9):3678-3686.
8. Han D, Ren XH, He XY, Chen XS, Pang X, Cheng SX*. Aptamer/peptide-functionalized nanoprobe for detecting multiple miRNAs in circulating malignant cells to study tumor heterogeneity. ACS Biomater Sci Eng. 2023 Sep 7.
9. Xu C, Ren XH, Han D, Peng Y, Lei JJ, Yu LX, Liu LJ, Xu WC, Cheng SX*. Precise detection on cell-cell fusion by a facile molecular beacon-based method. Anal Chem. 2022 Dec 13;94(49):17334-17340.
10. He XY, Ren XH, Peng Y, Zhang JP, Ai SL, Liu BY, Xu C, Cheng SX*. Aptamer/peptide-functionalized genome-editing system for effective immune restoration through reversal of PD-L1-mediated cancer immunosuppression. Adv Mater. 2020 Apr;32(17):e2000208.
1. 国家自然科学基金，仿生型小环状DNA传递系统用于增强肿瘤免疫治疗，2024/01-2026/12, 主持；
2. 安徽省高等学校自然科学研究重点项目，2023/01-2024/12, 主持；
3. 安徽医科大学引进人才科研启动项目，2022/07-2027/07, 主持.
