2021.01-至今         安徽医科大学生命科学院， 校聘副教授

2020.04-2021.01   金斯瑞， 高级科学家

2015.12-2019.11   匹兹堡大学医学院，博士后

2010.09-2015.10   东南大学医学院，博士

2006.09-2010.07   蚌埠医学院，学士

研究方向：

异基因造血干细胞移植(Allo-SCT)是治疗高危恶性血液病的选择之一，也是唯一有治愈可能的治疗手段。Allo-SCT的治疗效果主要归功于供体来源同种反应性ab T细胞（Alloreactive T cell， Allo-T），识别并杀伤leukemia，介导移植物抗白血病效应(Graft versus leukemia, GVL)。供体的Allo-T同样可以针对宿主健康组织，这被称为移植物抗宿主病(Graft versus host disease，GVHD)。GVHD和移植后leukemia的复发是影响患者存活率的主要障碍。因此，本实验室目前的研究工作集中在三个方向：

1. Allo-T介导GVL的相关机制；

2. 决定GVL sensitive或者GVL resistance的leukemia内在因素，并在此基础上，寻找潜在的治疗靶点；

3. 寻求有效防治GVHD发生而不引起免疫抑制，且能保留良好GVL效应的方法。

1. Meng Zhou, Faruk Sacirbegovic, Kai Zhao, Sarah Rosenberger, and Warren D Shlomchik*. Mechanisms of GVL-resistance: T cell exhaustion and a failure of antigen cross-presentation. Nature communications; 2020 Aug 24;11(1): 4227

2. Meng Zhou#, Zhifa Wen#, Feng Cheng#, and Li-Xin Wang*. Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-κB signal pathway, Oncoimmunology. 2016. PMCID: PMC5006924

3. Zhou M#, Li W#, Sheng Y#, Ren H, Dong H, Cao M, Hu HM, Wang LX*. Macrophages enhance tumor-derived autophagosomes (DRibbles)- induced B cells activation by TLR4/MyD88 and CD40/CD40L. Exp Cell Res. 2015;331(2):320-330. 

4. Li W#, Zhou M#, Ren H#, Hu HM, Lu L, Cao M, Wang LX*. Tumor-derived autophagosomes (DRibbles) induce B cell activation in a TLR2-MyD88 dependent manner, PLoS One. 2013;8(1):e53564. PMCID: PMC3541185 (co- authors)

5. Zhang Y, Pan N, Sheng Y, Zhou M, Wang LX*. Hypoxia enhances IL-10-producing B cell generation through upregulating high-mobility group B1 on tumor cell-released autophagosomes, Immunology Letters. 2019 Sep 27;216:36-42. PMID:31568811

6. Zhi-Fa Wen, Hongxiang Liu, Rong Gao, Meng Zhou, Wang LX*. Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1, J Immunother Cancer. 2018; 6: 151. PMCID: PMC6299637

7. Catherine Matte-Martone, Jinling Liu, Meng Zhou, Maria Chikina, Douglas R. Green, John T. Harty, and Warren D. Shlomchik*. Differential requirements f[or] myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity, The journal of Clinical Investigation. 2017;127(7):2765-2776. PMCID: PMC5490746

8. Aldarouish M, Wang H, Zhou M, Hu HM, Wang LX*. Ubiquitinated proteins enriched from tumor cells by a ubiquitin binding protein Vx3(A7) as a potent cancer vaccine, J Exp Clin Cancer Res. 2015 Apr 16;34:34. doi: 10.1186/s13046-015-0156-3. PMCID: PMC4405905

9. Ren H, Zhao S, Li W, Dong H, Zhou M, Cao M, Hu HM and Wang LX*. Therapeutic antitumor efficacy of B cells loaded with tumor-derived autophagasomes vaccine (DRibbles). J immunotherapy. 2014; 37(8):383-393. PMCID: PMC4166015

国家自然科学基金青年项目，82100197，BP-CML对供者髓样DC1的影响及其在介导GVL耐受中的作用研究，2022/01-2024/12，主持。